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Since free testosterone diffuses into a target organ a
2020-06-08
Since free testosterone diffuses into a target organ [1], a remarkable increase in free testosterone in plasma is expected to enhance androgen response in target organs including the prostate. In fact, the results of the present study showed testosterone and DHT levels, and mRNA expression levels of
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br Materials and methods br Results br Discussion CDK and
2020-06-08
Materials and methods Results Discussion CDK and their regulatory cyclins form a family of heterodimeric kinases that are particularly important for regulation of PKI-402 australia progression and transcription in tumor cells. These kinases therefore constitute biomarkers of proliferation
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Treatment related adverse events have
2020-06-08
Treatment-related adverse events have been a serious issue in clinical application. Severe toxicity has been reported in clinical trials using antibody blockade of CSF-1R (20 mg/kg), PD-1, and CTLA-4.29, 30, 31 However, apparent side effects were not observed in our study with PLX3397 treatment alon
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br Pre clinical combination studies using CSF
2020-06-08
Pre-clinical combination studies using CSF-1/CSF-1R inhibitors In preclinical models, the CSF-1R pathway can be blocked by using either small molecule kinase inhibitors (GW2580 [30], PLX3397 [31], Ki20227 [32], BLZ945 [33] and CYC11645 [34]), antibody-mediated inhibition of CSF-1 using 5A1 [35] o
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Nuclear export mediated by CRM is initiated by an
2020-06-08
Nuclear export mediated by CRM1 is initiated by an interaction between RanGTP and the HEAT9 loop of CRM1, triggering a conformational change in the NES binding site that permits NES–cargo protein binding (Dong et al., 2009, Fung and Chook, 2014). Our docking simulation results predicted that DP2392-
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In the original ELF study patients were considered
2020-06-08
In the original ELF study [7], patients were considered eligible if they were due to undergo liver biopsy for the investigation of chronic liver disease, defined as abnormal biochemical liver function tests persisting for more than 6 months, ability to provide informed consent and age between 18 and
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Senegenin Nevertheless two problems exist in BGCFC in
2020-06-08
Nevertheless, two problems exist in BGCFC in practice. The first one is that time complexity of the ID assignment algorithm presented in Section 3.1 is O(N!), which means a factorial time complexity. Because it obtains the consecutive IDs by enumerating all permutations of ID 0 to N−1, the total num
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br Conclusion br Introduction The morphological
2020-06-08
Conclusion Introduction The morphological variability of aquatic plants is well documented, and in some cases has seriously constrained taxonomic resolution (Sculthorpe, 1967, Santamaría, 2002). Many of these variations are caused by the extensive phenotypic plasticity of aquatic plants, but t
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Materials and methods br Results br Discussion Microbial
2020-06-08
Materials and methods Results Discussion Microbial production of trans-4Hyp, an added-value amino ARQ 197 for pharmaceuticals, offers significant advantages over conventional chemical extraction in economic and environmental aspects. However the low titer and productivity with the existing t
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br Diseases which have been treated with
2020-06-05
Diseases which have been treated with proteins linked to HSA A number of therapeutic products conjugated to HSA have now been approved for clinical use (Table 2). For example, fatty Golgicide A derivatives of human insulin bound to HSA have applications in the treatment of diabetes while paclitax
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br Introduction Melatonin mainly originates from the pineal
2020-06-05
Introduction Melatonin mainly originates from the pineal gland (Reiter, 1991) and is well known for its physiological functions in the regulation of circadian rhythms (Cajochen et al., 2003) and as a potent free radical scavenger and broad-spectrum antioxidant in mammals (Paradies et al., 2010, T
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A growing number of other post translational modifications
2020-06-05
A growing number of other post-translational modifications are implicated in regulation of the ubiquitin system, including substrate modification by hydroxylation, glycosylation, acetylation, methylation, modification by poly(ADP-ribose) (PAR), and attachment of ubiquitin-like modifiers. The HIF1-α
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In addition to glutamatergic inputs the RTn integrates choli
2020-06-05
In addition to glutamatergic inputs, the RTn integrates cholinergic, serotonergic and noradrenergic synapses of fibers coming from nuclei located in the brainstem (Asanuma, 1992, Morrison and Foote, 1986, Pare et al., 1988) involved in the alternating firing mode and in the frequency changes of reti
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Given the structural similarity of BMAA to other amino acids
2020-06-05
Given the structural similarity of BMAA to other amino acids, our hypothesis was that N-nitrosation of BMAA might result in a toxic alkylating agent, providing a previously unrecognised mechanism for BMAA action. Materials and methods Results and discussion We first examined whether chemical
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Numerous studies have pointed to the
2020-06-05
Numerous studies have pointed to the DGAT reaction being critical for TAG assembly and in several cases it has been shown to limit carbon flux from lipid precursors towards TAG accumulation [12]. Thus, in Brassica napus, the DGAT substrate, diacylglycerol (DAG), accumulates during periods of rapid l
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