• br Conclusion We present here the first comprehensive analys

  2024-10-16

  

  Conclusion We present here the first comprehensive analysis of B-Raf-induced transcriptional activation in insulinoma cells. The B-Raf-induced signaling cascade targets the c-Fos and the c-Jun genes. Both gene products are constituents of the AP-1 transcription factor. The phosphatases MKP-1 and

• br Materials and methods br

  2024-10-15

  

  Materials and methods Results Discussion Endophilin A1 is a membrane-binding protein that is mainly distributed in the central nervous system (Giachino et al., 1997), localizes in the dendritic shafts and spines of mature neurons (Yang et al., 2015), and relates to the function and morpholo

• Aberrant lipid levels are associated with various disorders

  2024-10-15

  

  Aberrant lipid levels are associated with various disorders, including vascular diseases and diabetes. Furthermore, important events support the idea that lipids, especially cholesterol and its derivatives, have a fundamental role in the physiopathology of AD. The p-selectin is rich in cholesterol,

• Through systematic deletion of AhR in specific

  2024-10-15

  

  Through systematic ezh2 inhibitor of AhR in specific cell types, Di Meglio et al. (2014) revealed that AhR in keratinocytes and fibroblasts are key to the exacerbated psoriatic phenotype induced by IMQ in AhR-deficient mice. This emphasizes the crosstalk between keratinocytes and the immune system t

• br Transparency document br Introduction

  2024-10-15

  

  Transparency document Introduction G protein-coupled receptors (GPCRs) comprise a diverse family of seven transmembrane domain-containing receptors represented by over 800 genes in humans. GPCRs respond to a range of stimuli, including peptides, hormones, growth factors, lipids, odorants, and

• Control of retinal vascularization during development and OI

  2024-10-15

  

  Control of retinal vascularization during development and OIR likely involves close interactions among endothelial cells, neurons and glial AZ191 (microglial and astrocytes) (see Fig. 2). In particular, the interaction between endothelial tip cells and astrocytes plays a critical role in development

• In the past years the role of the CD adenosinergic

  2024-10-15

  

  In the past 10 years, the role of the CD73-adenosinergic pathway in suppression of anti-tumor immunity has increasingly been recognized [13], [14]. In this review, we discuss the latest findings dealing with the regulation of anti-tumor immunity by CD73 and adenosine. We also discuss ongoing clinica

• We also investigated the transmittance

  2024-10-15

  

  We also investigated the transmittance of actin polymerized with and without ABP. The presence of actin in the solution results in an increment in turbidity as other proteins provided Zoniporide dihydrochloride australia features [21], [32]. While G-actin showed a transmittance peak positioned at 2

• Our studies also reveal the normal functional roles

  2024-10-15

  

  Our studies also reveal the normal functional roles of the MIR. Interaction between the MIR loop and the N-terminal α helix nucleates conformational maturation of AChR subunits, thereby promoting assembly of mature AChRs [52], [55]. This interaction in homologous parts of all AChR subunits appears t

• mecamylamine receptor Introduction Myasthenia gravis MG is

  2024-10-15

  

  Introduction Myasthenia gravis (MG) is an autoimmune disorder characterized by muscle weakness, which is mainly due to autoantibodies reducing the number or function of postsynaptic mecamylamine receptor receptors (AChRs) [1], [2]. Animal models have been developed to uncover the immunopathogenesi

• Concerning asthma in a study evaluating the effect of tiotro

  2024-10-15

  

  Concerning asthma, in a study evaluating the effect of tiotropium in severe asthma, the sputum eosinophil count and exhaled nitric oxide were also assessed. However, evaluation of the anti-inflammatory effect of tiotropium was difficult because these markers were low at baseline and thereafter. In a

• To date more than different mutations in the gene

  2024-10-15

  

  To date, more than 50 different mutations in the gene have been described (Human Gene Mutation Database at the Institute of Medical Genetics in Cardiff: SRD5A2 Gene: http://www.hgmd.cf.ac.uk). Most of them are missense mutations but premature stop codons and deletions leading to non-functional or su

• While the yeasts and see Glossary

  2024-10-14

  

  While the yeasts and (see Glossary) each contain only one Aurora homolog, Ipl1p (increase in ploidy 1) and Ark1 (Aurora-related kinase 1), respectively 5, 6, , and Xenopus laevis contain two Aurora kinases: Aurora A and Aurora B [4]. Mammals have three Aurora kinases, A, B, and C (Figure 1). In an

• Introduction An association of elevated branched chain amino

  2024-10-14

  

  Introduction An association of elevated branched-chain Pergolide mesylate (BCAA—Leu, Val, Ile) with obesity and insulin resistance was first reported nearly 50 years ago (Felig et al., 1969). With the advent of metabolomics technologies, it has since become apparent that the association of BCAA an

• BI-7273 Given the recent discovery of regions of single stra

  2024-10-14

  

  Given the recent discovery of regions of single-stranded DNA in the nuclei of hypoxic cells, the role for ATR in the response to hypoxic stress seems clearer . Zou and Elledge demonstrated that both Ddc 2 (the homolog of ATRIP) and ATRIP have a lower affinity for double-strand breaks than they do f

15685 records 21/1046 page Previous Next First page 上5页 2122232425 下5页 Last page