• br Conclusions The data presented here demonstrate

  2018-11-12

  

  Conclusions The data presented here demonstrate that MSX2 induces dedifferentiation with partial cell cycle re-entry in postmitotic multinucleated mammalian muscle cells. Our pharmacological treatment recapitulates MSX2-induced dedifferentiation and exhibits potential for future therapeutic proto

• All PGCs differentiated from ESCs in our study regardless of

  2018-11-09

  

  All PGCs differentiated from ESCs in our study, regardless of differentiation approach or sorting strategy, were capable of implementing ICC erasure at the Snprn ICC. However, unlike E9.5 PGCs from the embryo, the hypomethylated state at this ICC was unstable, and in every case re-methylation was in

• Due to the major differences in phenotype

  2018-11-09

  

  Due to the major differences in phenotype between human and murine GATA6 disease models, human pluripotent stem cells (PSCs) offer an alternative system for the in vitro study of GATA6. With recent developments in the genome-editing field, the use of clustered regularly interspaced short palindromic

• Main Text In so many

  2018-11-09

  

  Main Text In so many ways the field is stronger than ever, with terrific progress in stem cell research and discovery that has led to advances in regenerative medicine. We see research moving toward the clinic at a greater rate, with new treatment approaches showing real promise. The last 15 years

• e3 ligases As above mentioned in both

  2018-11-09

  

  As above-mentioned in both countries (the Netherlands and the Philippines), pride is an important driver of both sales performance and citizenship behaviors. Therefore it is important for managers to instill pride in their salesforce as it has broaden-and-build effects on other emotions (Fredrickson

• After PN pups show a rapid transition

  2018-11-09

  

  After PN15, pups show a rapid transition to independence and by weaning age (∼PN23), they show stress-induced activation of the HPA axis similar to adult-like levels. At this age, the relative ability of the mother to decrease the pups’ adult level stress hormone response is greatly reduced and leav

• Disclosure br High grade serous ovarian cancer

  2018-11-09

  

  Disclosure High-grade serous ovarian cancer (HGSOC) has a high mortality rate because the disease is asymptomatic in early stages and is resistant to treatments. A novel modality for diagnosis in the early stages of carcinogenesis is needed. In this issue of , Hellner et al. present novel genetic

• br Materials Methods br Results

  2018-11-09

  

  Materials & Methods Results To better understand how ZIKV infection may lead to microcephaly, we developed an assay to infect cultured mouse embryonic the Argonaute family of proteins slices and tested the ability of ZIKV and other flaviviruses to infect the neocortex (Fig. 1a). We selected a

• Disclosure br High grade serous ovarian cancer

  2018-11-09

  

  Disclosure High-grade serous ovarian cancer (HGSOC) has a high mortality rate because the disease is asymptomatic in early stages and is resistant to treatments. A novel modality for diagnosis in the early stages of carcinogenesis is needed. In this issue of , Hellner et al. present novel genetic

• Although it can be hypothesized

  2018-11-09

  

  Although it can be hypothesized that sodium butyrate alterations also play a role in the complex persistent complaints of patients with chronic whiplash-associated disorders (WAD), these changes remain poorly investigated. Therefore, the , recently published in , is of great scientific and clinical

• In conclusion the number of tumours tumour size BCG instilla

  2018-11-09

  

  In conclusion, the number of tumours, tumour size, BCG instillation, and intravesical instillation of chemotherapy were found to be independent predictors for time to recurrence after TUR-Bt in Japanese patients with NMIBC. Our novel, simple, and prognostic classification may not only predict the re

• br Methods br Results br Discussion

  2018-11-09

  

  Methods Results Discussion Mechanical stretch via tissue expanders stimulates proliferation and maturation in both embryonic and adult purchase 5z (Mihic et al., 2014; Banerjee et al., 2015). In adult skin, mechanical tension induces fibroblasts proliferation and collagen synthesis (Wong et

• br Numerous studies have reported H the first discovered

  2018-11-09

  

  Numerous studies have reported H19, the first discovered long non-coding RNA (lncRNA), to have key regulatory functions in tumor development and progression (). This paternally imprinted gene is located close to the telomeric region of chromosome 11p15.5 that frequently harbors genetic alterations

• Peri operative use of opioid analgesic

  2018-11-09

  

  Peri-operative use of opioid analgesic medications-including Patient controlled analgesia (PCA) further increases the risk of such complications [5,6]. Prevention of these adverse events may be made possible by appropriate post-operative SPo2 and Etco2 monitoring [7]. O2 supplementation is required

• Because commercially available immunoassay presents limited

  2018-11-09

  

  Because commercially available immunoassay presents limited detection sensitivity on detecting low-abundance cancer biomarkers against the background of high-abundance bax pathway proteins. Recently, gold nanomaterials (GNPs) show unique optical properties and high surface areas, which have been us

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